OK, I know this is probably off on a tangent, but...
Makehuman is really great for creating realistic human bodies, but this can be easily defiled by posing, whereby skeletons can be rotated into impossible angles.
How could we take makehuman to the next level by creating human-real limits on the skeleton to limit the poses to realistic poses?
This is very much an open question on the theory of how to achieve it!
Mat