My custom folder inside MakeHuman/Home has hundreds of targets. Leaving them all inside one folder caused the list of sliders to become overwhelming to the point of taking a lot of time just to find the desired control. So, I did the logical thing. I created sub folders and put the relevant targets inside of them.
Now that the targets are sorted, they become much easier to find. When I select custom, the sliders are still in the left pane, but the right pane is now populated with the folders. Selecting a folder brings up those targets it contains in the left pane.
Thus, I spend much less time hunting down a given target and much more time playing with the sliders. It streamlines my work flow tremendously!